Tablet Disintegration Tester Series DTG

Jumlah
Habis



The Tablet Disintegration Tester Series DTG is the result of over 50 years experience in the field of pharmaceutical testing.

The series is available with one (DTG 1000), two (DTG 2000), three (DTG 3000) or four (DTG 4000) test stations. Each individual test station is capable of accepting one batch of six tablets or capsules. The DTG 2000IS is also available, which has two test stations, but with independent control over each test station.

All Copley Tablet Disintegration Testers feature:

  • Sturdy, robust design including novel “quick release” basket(s), one-piece water bath and independent digital heater/circulator
  • Simple, easy to use operation ensures that the number of operations required to perform a test are kept to a minimum
  • Full supporting documentation (including full IQ/OQ/PQ qualification documentation if required)
  • Special accessories available for hard/soft gelatine capsules and large tablets, capsules and boluses

Disintegration Testing

It has long been recognised that before a tablet/hard gelatine capsule can dissolve and hence allow the active drug to be absorbed into the body, it must first disintegrate into smaller particles.

The current apparatus described in the Pharmacopoeias was designed to provide a reproducible and standardised method of ensuring that disintegration has taken place. Each of the tablets to be tested is placed in one of 6 vertical tubes arranged in a circular basket arrangement. The lower end of the tubes is covered by a sieve mesh.

During testing, the basket assembly is raised and lowered in simulated gastric fluid at 37 degrees C whilst the tablet is continually “hammered” by a plastic disk of defined proportions to simulate in vivo conditions.

The tablet is said to pass the test providing that no tablet residue remains on the mesh after the designated test period.

Disintegration Tester Accessories

Copley Scientific offers a complete range of accessories for
use with the DTG series, from complete basket rack assemblies to individual tubes, disks and sieve meshes.

All parts are manufactured to tolerances that are equal to or
better than those quoted in the respective Pharmacopoeias and carefully checked prior to despatch.

Two of the more popular items of interest are:

Basket Rack Assembly cover for hard and soft gelatine capsules (as per USP Chapter <701>).
Converts standard basket to special cover version for testing hard or soft gelatine capsules according to USP Chapter <701>.

Special Basket Rack Assembly for Large Tablets and Capsules.
Special basket rack assembly for large tablets, capsules and boluses according to Ph.Eur. Chapter 2.9.1 Test B and for dietary supplements according to USP Chapter <2040>.